Genetic Architecture: Dissecting the Genetic Basis of Phenotypic Variation

Genetic Architecture: Dissecting the Genetic Basis of Phenotypic Variation

Identifying genes that influence phenotypic variation within species has proven to be more difficult than expected. A recent study has achieved exceptional success in yeast, and demonstrates how complex genetic architecture can be.

Dissecting the genetic basis of myoclonic-astatic epilepsy.

Herman Doose first described the generalized childhood epilepsy syndrome of myoclonic astatic epilepsy (MAE) in 1970, attributing a genetic cause from this first description. However, although the International League Against Epilepsy (ILAE) defined criteria for MAE in 1989, the diagnostic boundaries of the syndrome continue to be debated. Moreover, 40 years since Doose's first description of M...

Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation

Although single genes underlying several evolutionary adaptations have been identified, the genetic basis of complex, polygenic adaptations has been far more challenging to pinpoint. Here we report that the budding yeast Saccharomyces paradoxus has recently evolved resistance to citrinin, a naturally occurring mycotoxin. Applying a genome-wide test for selection on cis-regulation, we identified...

Unraveling the Genetic Architecture of Cryptic Genetic Variation

phylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran

in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...